Medication & desire, read by a sex therapist · 8 min read
GLP-1s, “Reta” and Your Sex Drive: What We Know and What We Don’t
Ozempic, Wegovy, Mounjaro, Zepbound — and now black-market retatrutide. People are noticing changes in desire. Here is what the research actually shows, what is still guesswork, and what to do if it’s happening to you.
Written and clinically reviewed by Vanessa Cushing, LPC, NCC, MS — AASECT-Certified Sex Therapist, licensed in Virginia & Florida. The Cushing Counseling team covers Virginia, DC, Maryland & Florida.
The short answer
GLP-1 drugs can change sex drive in either direction. Weight loss often improves sexual function and confidence, but some people report lower desire, harder orgasms or erection problems, and one large records study linked semaglutide to more erectile dysfunction diagnoses in younger men. Retatrutide (“reta”) is not approved, and no trial has measured its effect on libido. If your desire has changed, tell your prescriber and consider a sex therapist.
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Why people are asking
Millions of people now take GLP-1 medications such as semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound). These drugs quiet appetite and what many patients call “food noise.” A growing number of them, and their partners, are noticing that something else feels quieter too.
The newest version of the question is about retatrutide, nicknamed “reta.” It is Eli Lilly’s experimental “triple” drug, acting on GLP-1, GIP and glucagon receptors. In April 2026 the Guardian reported on viral TikTok videos claiming reta was “ruining relationships” and could make people “fall out of love,” with commenters describing lost cravings, lost lust and emotional flatness.
First: what retatrutide is, and isn’t
Retatrutide is not approved by the FDA or any other regulator. As of Lilly’s own September 2026 update, it is available only to people in Lilly’s clinical trials, and Lilly says it plans to file for approval in early 2027. Lilly warns that no one should take anything claiming to be retatrutide outside a trial.
That matters, because much of the reta being used today is bought online as a “research peptide.” Lilly says it has found products with too much, too little or the wrong ingredient, plus contaminants. CBS News reported in October 2026 that the FDA had received two reports of deaths in people using bootleg retatrutide (cause unverified), and that poison centres logged 862 retatrutide exposures in the three months to September, up from 249 in the first quarter of the year.
So when someone on TikTok says reta changed their sex drive, we often can’t know what was in the vial, at what dose, or what else was going on.
What the research shows about GLP-1s and sex
Research on sex and these medications is early, and the findings point in different directions. That is not a dodge — it is the honest state of the evidence.
- Weight loss itself often helps. A 2025 review in Sexual Medicine Reviews notes that sexual problems are a common, under-recognised part of obesity, and that losing weight is linked to better sexual health.
- But one large records study raised a flag for men. Researchers using the TriNetX database compared 3,094 non-diabetic men aged 18–50 with obesity who were prescribed semaglutide against 3,094 similar men who weren’t. New erectile dysfunction diagnoses or ED prescriptions were 1.47% vs 0.32%, and low-testosterone diagnoses 1.53% vs 0.80% (International Journal of Impotence Research, 2024). That is an association, not proof the drug caused it — and the absolute numbers are still small.
- Women’s reports are newer. A 2025 case report in Sexual Medicine describes a woman who lost the ability to orgasm after starting a GLP-1 medication, and proposes possible reasons involving blood flow and the brain’s reward chemistry. A single case can’t tell us how common this is.
- Bigger studies are underway. Mayo Clinic, for example, is running a study of sexual function in postmenopausal women on GLP-1 therapies.
- Retatrutide specifically: no published trial has reported sex drive as a measured outcome. Anything said about reta and libido right now is anecdote or extrapolation from the older drugs.
Why desire might change — the possible reasons
Desire is never just one thing, so a medication rarely affects it in one simple way. The leading ideas researchers and clinicians are exploring include:
- The reward system. GLP-1 drugs act on brain areas tied to craving and reward. Some scientists wonder whether, in some people, quieting the pull toward food also quiets other pulls. This is a hypothesis, not a settled finding.
- Feeling unwell. Nausea, constipation, fatigue and eating much less are common, especially when doses go up. It is hard to feel sexy when you feel queasy and tired.
- Hormones and blood flow. Rapid weight change can shift hormone levels, and some researchers think these drugs may affect blood flow involved in arousal and orgasm.
- Body image, in both directions. Many people feel more confident as their body changes. Others feel exposed, unfamiliar in their own skin, or anxious about being desired for a new body.
- The relationship. When one partner changes quickly, the couple’s balance can shift: who initiates, how meals and evenings look, how each partner feels seen.
If it’s happening to you
Don’t stop or change a prescribed medication on your own. These drugs are often treating real health conditions, and the trade-offs are a decision for you and your prescriber together.
- Tell your prescriber specifically: “My desire / erections / orgasms have changed since I started.” It is a legitimate side effect to report, not a vanity complaint. Dose timing or other options may help.
- Notice the pattern. Is it worse in the days after a dose, or during a dose increase? Is it tied to nausea or exhaustion? That detail helps your clinician.
- Separate desire from arousal. Many people find that responsive desire — the kind that shows up once touch begins — is still there, even when spontaneous desire is quiet.
- Talk to your partner early, before silence becomes a story about rejection. “This is the medication, not you” is a sentence worth saying out loud.
- If you’re using research-peptide reta, please tell a doctor. You don’t have to be judged to be safe, and they can’t help with side effects they don’t know about.
How sex therapy helps
A sex therapist won’t prescribe or adjust your medication. What we do is help with everything around it: rebuilding desire that runs on connection rather than urgency, working through body-image changes, reducing pressure around erections or orgasm, and helping couples talk about a shift neither of them chose.
We also coordinate with your medical team when it helps, so the physical and emotional sides are looked at together instead of one at a time.
Frequently asked questions
Do GLP-1 drugs like Ozempic lower your sex drive?
Some people report lower desire, but others report improvement as they lose weight and feel better in their bodies. Research is still early and points both ways. If your sex drive changes, tell your prescriber.
Does retatrutide (reta) affect libido?
Nobody knows yet. Retatrutide is unapproved, and no published trial has measured its effect on sex drive. Reports of lower libido on reta come from social media and are often linked to unregulated products of unknown content.
Can semaglutide cause erectile dysfunction?
A 2024 records study found that non-diabetic men aged 18–50 prescribed semaglutide had more new ED diagnoses than similar men who weren’t (1.47% vs 0.32%). It shows an association, not cause. Talk to your prescriber or a urologist if you notice changes.
Can GLP-1 medications affect orgasm in women?
There are early reports, including a 2025 published case of a woman who could no longer orgasm after starting one. Studies in women are now underway. If it happens to you, raise it with your prescriber and consider a sex therapist.
Should I stop my GLP-1 if my sex drive drops?
Not on your own. Talk to the clinician who prescribed it about the change and your options. A sex therapist can help with desire, arousal and relationship strain alongside your medical care.
Is it safe to buy retatrutide online?
Lilly, its maker, says no one should take anything claiming to be retatrutide outside a Lilly clinical trial. Online products have been found with the wrong dose, wrong ingredient or contaminants, and the FDA has received reports of deaths in people using bootleg versions.
Keep reading
- Sex Therapy — For desire, arousal and orgasm concerns.
- Sex recession data — Why Americans are having less sex.
Also on this site
Clinical resources this page draws on
- Able et al., semaglutide and erectile dysfunction (Int J Impot Res, 2024)
- Anorgasmia following initiation of GLP-1 agonist (Sexual Medicine, 2025)
- Beyond metabolism: sexual dysfunction and weight-loss drugs (Sexual Medicine Reviews, 2025)
- Eli Lilly: What to know about retatrutide (Sept 2026)
- CNBC: Lilly to file for retatrutide approval in 2027
- CBS News: deaths reported to FDA after bootleg “reta”
- The Guardian: Is a new weight-loss drug making people fall out of love?
- Mayo Clinic study: GLP-1 therapies and sexual health in postmenopausal women
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